Document#1B

Below, is a letter from E. Larsen sent to me when she was on sabbatical year in Berkeley. Thetext of the letter reads:24 April '83Dear Michael,I just talked to George Oster who had some things to say, as always. He keeps away fromgeometrical model because they are, according to him infinite outcomes when you do simulations.For example, he says that after digitizing the the vertices of cells in the disc and finding out whatthe mean cell side length is, the order of cells in which cell side length is equalized is importantin giving a final result. eg if you have 4 cells and you equalized sides of cell 1 then 2 then 3 thenand projected the image it would be a different image than if you started with cell 2 then 4 then 1then 3. Is this true? He suggested staining discs between 3 rd instar and evagination to see iftheir is a [......] sequence of equalizing sides: eg is there a wave as in the eye disc?In terms of characterizing cell patterns of different discs or the same disc through time hesuggested plotting the relationship between cell perimeter, side length and cell area for cells of adisc and see if there are disc specific distributions.Any comments? Can you send me the citation for the article showing division wave in the crypt?(Cell and Tissue Kinetics)Regards Ellie

She never understood my work, even the simple things in it. She was peddling things that she didnot understand and could hardly communicate correctly. Nor could she understand the answers.(Evidently, in her example when the length of cell sides in a polygonal mosaic is consecutivelyequalized, the result depends on the choice of the first side.) The "equalization" of sides (but,rather, cells, equally enlarging their surface area and appearing like a sheet of almost similarpolygons) was my explanation for the process of morphogenesis, when a small, tightly packedwith cells disc develops into the adult appendage. I was convinced that, quite contrary to thereports published for years by this laboratory in Berkeley, cells do not change their positions inthe tissue, but only change shape, and that this alone should result in the new, adult shape of anappendage (an elastic transformation). Larsen sold or otherwise peddled this idea to them and,after 8 years, they confirmed the idea experimentally (see my reference #6 to the article"....... ANovel Morphogenetic Mechanism"). Alas, in this article they quoted Larsen's article of 1989(where she plagiarized my Ph.D. research) as a discovery of peculiar cell arrangements in thediscs of Drosophila. She, herself, could not accomplish anything and the grant that shefraudulently procured was taken away from her.

Here is her letter: